Efficient Microwave-Assisted Synthesis of 5-Deazaflavine Derivatives

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Efficient microwave-assisted synthesis of 5-deazaflavine derivatives.

A series of pyrimido[4,5-b]quinolines (5-deazaflavines), were synthesized by microwave assisted intramolecular cyclization. The N⁴-substituted-2,4-diamino-6-chloro-pyrimidine-5-carbaldehydes, were prepared by selective monoamination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde with aliphatic and aromatic amines.

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ژورنال

عنوان ژورنال: Molecules

سال: 2010

ISSN: 1420-3049

DOI: 10.3390/molecules15107227